Letrozole Tablets – Uses, Benefits, Side Effects & Precautions
Letrozole is a widely prescribed medication used primarily in the treatment of hormone-responsive breast cancer in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors, which work by reducing estrogen levels in the body. By lowering estrogen, Letrozole helps slow or stop the growth of certain cancer cells that depend on this hormone.
What Is Letrozole?
Letrozole is an oral, prescription-only medication commonly marketed under various brand and generic names. It is mainly used as part of long-term therapy for estrogen receptor-positive (ER+) breast cancer. In some cases, it may also be prescribed for other hormone-related conditions under medical supervision.
How Letrozole Works
Letrozole works by blocking the enzyme aromatase, which is responsible for converting androgens into estrogen in postmenopausal women. By inhibiting estrogen production, Letrozole reduces the hormonal stimulation of cancer cells, helping to prevent cancer progression or recurrence.
Uses of Letrozole
Letrozole is commonly used for:
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Treatment of early and advanced breast cancer in postmenopausal women
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Hormone-positive breast cancer after surgery or radiation
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Preventing recurrence of breast cancer
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As extended adjuvant therapy following tamoxifen treatment
⚠️ Letrozole should only be used under the guidance of a qualified healthcare professional.
Benefits of Letrozole
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Effectively lowers estrogen levels
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Proven to reduce the risk of breast cancer recurrence
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Well-studied and widely prescribed worldwide
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Convenient once-daily oral tablet
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Suitable for long-term treatment plans
Possible Side Effects
Like all medications, Letrozole may cause side effects, although not everyone experiences them. Common side effects may include:
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Hot flashes
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Joint or muscle pain
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Fatigue
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Headache
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Increased sweating
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Bone thinning with long-term use
Serious side effects are rare but should be reported to a doctor immediately.
Precautions & Warnings
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Not recommended for premenopausal women unless specifically advised
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Not suitable during pregnancy or breastfeeding
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Patients with bone density issues should be closely monitored
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Inform your doctor about all medications and supplements you are taking
Storage Instructions
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Store Letrozole tablets at room temperature
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Keep away from heat, moisture, and direct sunlight
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Keep out of reach of children
Frequently Asked Questions (FAQ)
Is Letrozole a chemotherapy drug?
No. Letrozole is a hormone therapy, not chemotherapy.
How long is Letrozole treatment usually taken?
Treatment duration varies depending on the condition and medical advice, often ranging from several months to years.
Can Letrozole be taken daily?
Yes, it is typically taken once daily as prescribed by a doctor.

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