Aromasin – 10mg- 50 Tabs

Exemestane: Uses, Benefits, Dosage, and Side Effects

Exemestane is a widely used aromatase inhibitor prescribed primarily for the treatment of hormone-receptor-positive breast cancer in postmenopausal women. It works by reducing estrogen levels in the body, helping to slow or stop the growth of estrogen-dependent cancer cells.

What Is Exemestane?

Exemestane is an oral, steroidal aromatase inhibitor that blocks the enzyme aromatase, which is responsible for converting androgens into estrogen. By lowering estrogen levels, Exemestane helps reduce the risk of cancer progression and recurrence.

It is commonly marketed under the brand name Aromasin, though high-quality generic versions are also available.

Uses of Exemestane

Exemestane is primarily used for:

• Treatment of estrogen-receptor-positive breast cancer

• Extended adjuvant therapy after tamoxifen treatment

• Reducing the risk of breast cancer recurrence

• Off-label use in hormone management protocols (under medical supervision)

How Exemestane Works

Exemestane irreversibly binds to the aromatase enzyme, preventing estrogen production. Unlike non-steroidal aromatase inhibitors, Exemestane permanently deactivates the enzyme, making it highly effective for long-term estrogen suppression.

Dosage and Administration

• Typical dosage: 25 mg once daily

• Should be taken after meals for better absorption

• Duration of treatment depends on medical condition and physician guidance

⚠️ Always follow your doctor’s prescription and never adjust the dosage without professional advice.

Benefits of Exemestane

• Effectively lowers estrogen levels

• Reduces the risk of breast cancer recurrence

• Suitable for long-term therapy

• Well-studied with proven clinical results

Possible Side Effects

Like all medications, Exemestane may cause side effects, which can include:

• Hot flashes

• Joint or muscle pain

• Fatigue

• Headache

• Nausea

• Decreased bone density with long-term use

If severe or persistent side effects occur, consult a healthcare professional immediately.

Precautions and Warnings

• Not recommended for premenopausal women

• Avoid use during pregnancy or breastfeeding

• Inform your doctor about existing liver or bone conditions

• Regular monitoring of bone health is advised

Exemestane vs Other Aromatase Inhibitors

Compared to other aromatase inhibitors like Anastrozole and Letrozole, Exemestane offers irreversible enzyme inhibition, making it a preferred option for certain patients after tamoxifen therapy.

Storage Instructions

• Store at room temperature

• Keep away from moisture and direct sunlight

• Keep out of reach of children

Frequently Asked Questions (FAQ)

Is Exemestane a steroid?
Yes, it is a steroidal aromatase inhibitor, but it does not have anabolic steroid effects.

How long does Exemestane take to work?
Estrogen levels begin to drop within days, but clinical benefits are seen over weeks to months.

Can Exemestane be taken long-term?
Yes, when prescribed by a doctor, it is often used for extended treatment durations.