Metribolone (Methyltrienolone): Benefits, Risks, and Key Information
What Is Metribolone?
Metribolone, also known as Methyltrienolone, is a synthetic anabolic-androgenic steroid (AAS) derived from trenbolone. It is known in scientific literature for being one of the most potent androgen receptor agonists ever studied. Due to its extreme strength and toxicity profile, metribolone is not approved for medical use and is primarily referenced in research and biochemical studies.
Chemical Overview
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Chemical Name: Methyltrienolone
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Classification: Synthetic anabolic-androgenic steroid
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Structure: 17-alpha alkylated trenbolone derivative
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Anabolic Rating: Extremely high
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Androgenic Activity: Extremely high
Metribolone’s methylation allows it to be orally active, but this same modification significantly increases liver strain.
Why Is Metribolone So Potent?
Metribolone binds exceptionally strongly to androgen receptors—far more than testosterone or most other anabolic compounds. This high binding affinity is the main reason it is often cited in research as a benchmark compound when studying androgen receptor activity.
Potential Effects (Theoretical / Reported)
In academic and anecdotal discussions, metribolone is associated with:
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Strong androgen receptor activation
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Increased nitrogen retention
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Enhanced protein synthesis (theoretical)
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Significant hormonal suppression
⚠️ These effects are discussed in research contexts, not as medical or fitness recommendations.
Health Risks and Safety Concerns
Metribolone is widely regarded as high-risk due to its side-effect profile:
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Severe liver toxicity (hepatotoxicity)
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Hormonal suppression
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Cardiovascular strain
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Androgenic side effects
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No established safe dosage
Because of these risks, metribolone is not used clinically and is generally avoided outside of laboratory research.
Legal Status
Metribolone is:
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Not approved for human use
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Often classified as a controlled or banned substance in many countries
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Prohibited by WADA and professional sports organizations
Always check local laws and regulations before handling or researching controlled compounds.
Research and Scientific Use
Today, metribolone is mainly referenced in:
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Androgen receptor studies
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Endocrinology research
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Comparative anabolic potency analysis
Its role is largely experimental, not therapeutic.

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